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Pyridostatin (RR82)
CAS No. 1781882-65-2
Pyridostatin (RR82) ( RR82 hydrochloride )
产品货号. M21863 CAS No. 1781882-65-2
Pyridostatin (RR82) 盐酸盐是一种 G-四链体 DNA 稳定剂 (Kd=490 nM)。 PyridostatinHCl 通过诱导复制和转录依赖性 DNA 损伤来促进人类癌细胞的生长停滞。盐酸吡啶他汀靶向原癌基因 Src。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥828 | 有现货 |
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| 10MG | ￥1071 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Pyridostatin (RR82)
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Pyridostatin (RR82) 盐酸盐是一种 G-四链体 DNA 稳定剂 (Kd=490 nM)。 PyridostatinHCl 通过诱导复制和转录依赖性 DNA 损伤来促进人类癌细胞的生长停滞。盐酸吡啶他汀靶向原癌基因 Src。
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产品描述Pyridostatin (RR82) hydrochloride (10 μM; 48 hours) induces cell cycle arrest.Pyridostatin hydrochloride is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin hydrochloride causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin hydrochloride induces the formation of DNA DSBs. Remarkably, Pyridostatin hydrochloride (1-5 μM, overnight) downregulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level.
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体外实验Pyridostatin (RR82) hydrochloride (10 μM; 48 hours) induces cell cycle arrest. Pyridostatin hydrochloride is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin hydrochloride causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin hydrochloride induces the formation of DNA DSBs. Remarkably, Pyridostatin hydrochloride (1-5 μM, overnight) downregulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level. Cell Viability Assay Cell Line:Over 60 different cancer cell lines Concentration:10 μM Incubation Time:48 hours Result:Predominantly accumulated in the G2 phase of the cell cycle over 60 different cancer cell lines.
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体内实验——
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同义词RR82 hydrochloride
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通路Cell Cycle/DNA Damage
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number1781882-65-2
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分子量778.94
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分子式C??H??Cl?N?O?
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纯度>98% (HPLC)
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溶解度H2O : 50 mg/mL (64.19 mM; Need ultrasonic)
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SMILESO=C(C1=CC(OCCN)=CC(C(NC2=NC3=C(C(OCCN)=C2)C=CC=C3)=O)=N1)NC4=CC(OCCN)=C5C=CC=CC5=N4.Cl.Cl.Cl.Cl.Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Rodriguez R, et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 2012;8(3):301-310. Published 2012 Feb 5.
2. Koirala D, et al. A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem. 2011;3(10):782-787. Published 2011 Aug 28.
3. Moruno-Manchon JF, et al. The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons. Aging (Albany NY). 2017;9(9):1957-1970.
产品手册
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Pyridostatin (RR82)
Pyridostatin (RR82) 盐酸盐是一种 G-四链体 DNA 稳定剂 (Kd=490 nM)。 PyridostatinHCl 通过诱导复制和转录依赖性 DNA 损伤来促进人类癌细胞的生长停滞。盐酸吡啶他汀靶向原癌基因 Src。
